At the beginning of the 19th century the region was one of the ten most industrialized in France. Many of these industries now belong to the historical heritage of the region. Haute-Saone has been able to preserve some of its various crafts, such as lace making in Luxeuil, glass blowing in Passavant-la-Rochere,...
The architectural wealth can be seen in each town and village where churches, castles, thermes, washhouses and fountains evoke its past.

The local gastronomy includes Luxeuil ham, cancoillotte cheese, local wines, Fougerolles Kirsch liquor and the dish called "Pauchouse", a freshwater fish stew.